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KMID : 0360220200610111391
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Journal of the Korean Ophthalmological Society
2020 Volume.61 No. 11 p.1391 ~ p.1398
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Secondary Open-angle Glaucoma and Vitreous Opacity as Presenting Manifestations of Familial Amyloid Polyneuropathy
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Park Kee-Sup
Kim Kyoung-Nam
Lee Han-Min
Koo Hyung-Moon
Kim Chang-Sik
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Abstract
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Purpose: We report a case of familial amyloid polyneuropathy in a patient presenting with open-angle glaucoma and progressive vitreous opacity.
Case summary: A 62-year-old female patient presented with uncontrolled intraocular pressure (IOP) in the left eye that did not respond to medical treatment. She had no history of systemic diseases other than hypertension. Trabeculectomy was performed in the left eye. Thirteen months later, as IOP in the right eye suddenly increased to 50 mmHg and was not controlled, trabeculectomy was also performed in the right eye. Anterior chamber angle was wide and open in both eyes and there were no abnormalities. Vitreous opacity increased gradually in both eyes. Neurological examination was conducted as the patient complained of numbness in the feet, and a diagnosis of familial amyloid polyneuropathy was confirmed.
Conclusions: Although rare, familial amyloid polyneuropathy and secondary glaucoma should be considered as differential diagnoses in open-angle glaucoma patients showing high intraocular pressure accompanied by progressive vitreous opacity.
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KEYWORD
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Familial amyloidosis, Glaucoma, Systemic disease, Vitreous
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